While Gizmo continues his quest to take over the world, Wedgie and his best friend, a micro-pig who lives next door, team up to stop him.

Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to give away his favorite, Astro.

Mariella Mystery tackles the case of the ghostly guinea pig. Is there really a phantom rodent on the loose?

While Piggie is determined to fly, Elephant is skeptical, but when Piggie gets a little help from others, amazing things happen.

The pigs, Pete and Paul, are eager to help Farmer Bill grow the best and biggest watermelons so he'll win at the annual Fruit and Vegetable Show, but their overzealous efforts to help the melons grow faster end up destroying the entire melon patch. Tractor Mac and friends teach Pete and Paul that with patience and care, they too can grow a prize melon.

A friendly lion escapes from the local zoo and Pig Pig wants to keep him.

While his human Elliot adjusts to his new home and stepfamily, Gizmo, an evil genius guinea pig, searches for a new evil lair where he can plot to take over the world, but Gizmo is constantly thwarted by Elliot's little stepsister Jasmine (who likes to play dress-up), Abuela (who may or may not like to eat cavies), and Wedgie (a Corgi superhero and Gizmo's nemesis).

"Flora the pig ditches the sedentary life on the farm for an adventure in Antarctica, where she escapes the knife and lives her dream of pulling a sled with a team of dogs"--

Piggie is upset because a whale took the ball she found, but Gerald finds a solution that pleases all of them.

Peggy the pig receives a mysterious call from the "Viper" warning that he is coming in one year, with repeated calls which count down the dwindling time until his arrival.