Dog Man, a crimefighter with the head of a police dog and the body of a policeman, faces off against his archnemesis Petey the cat. Dog Man, the newest hero from the creator of Captain Underpants, is still learning a few tricks of the trade. If only the Chief would throw him a bone every once and a while ... Dog Man needs to dry up the drool, dust away the dander, and roll out of the refuse if he's going to impress the Chief, and he needs to do it...

Petey the Cat is out of jail, and he has a brand-new lease on life. While Petey's reevaluated what matters most, Li'l Petey is struggling to find the good in the world. Can Petey and Dog Man stop fighting like cats and dogs long enough to put their paws together and work as a team? They need each other now more than ever -- Li'l Petey (and the world) is counting on them!

After an encounter with a skunk, Dog Man, now scarlet red after being dunked in tomato juice, is exiled but must find a way to save those who shunned him when an all-new, never-before-seen villain unleashes an army of A.I. robots.